Scientists may have found the cause of polycystic ovary syndrome

Sherry Tadeja
PUBLISHED June 14, 2018 11:37 am
Photo from Woman Yeah/Website

(Inside Manila) What makes infertility sadder is that it strips anyone (those who want to have children and those who even don't want) of the function to produce an offspring. And for female infertility, polycystic ovary syndrome is the most common.

Polycystic ovary syndrome better known as PCOS is commonly known caused by hormonal imbalance. A woman with PCOS also has high levels of testosterone, irregular menstrual cycles, and ovarian cysts that leads to difficulty in conception and sometimes infertility.

Fortunately, a recent report shed light as scientists may have finally traced back the cause of the syndrome.

In a report by the New Scientists, a group of researchers at the French National Institute of Health and Medical Research found out that over-exposure in the womb may have given birth to a hormone called anti-Müllerian that in turn triggers the syndrome.

They discovered that pregnant women with PCOS have 30% higher levels of the hormone than normal. Since PCOS is hereditary, researchers are trying to see if this hormonal imbalance in anti-Müllerian can be passed to the daughters as well.

The group tested the theory in pregnant mice where they inject an excess anti-Müllerian. Remarkably the offspring displayed symptoms of those who have the PCOS; later puberty, infrequent ovulation, difficulty in conception and if it did, few offspring.

And it seems like a cure is also on the way, as the team successfully revised the symptoms using an IVF drug used to control women's hormones.

The team is planning to do a clinical trial on women with the condition by the end of the year.

"It could be an attractive strategy to restore ovulation and eventually increase the pregnancy rate in these women," says Paolo Giacobini one of the researchers in the study.



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